CAN I RUN 700c AND 650B WHEELS?
Yes! So long as there is tire width clearance all traditional disc brake bikes work with 650B or 700C wheels.
Bikes are properly designed around a rolling diameter (wheel + tire), not a rim diameter, and a 650x47 setup is the same total diameter as a 700x28. (If you like numbers check out BikeCalc.com for a big ol' chart.)
Please note that part of what makes the Waypoint so stable and ideal for gravel, commuting, and touring is the low bottom bracket, so bikes with 175mm cranks can see increased pedal strike when cornering in cadence with a 650x40 or smaller tire.
WHAT SIZE TIRES FIT IN THE FRAME?
The short and only honest answer is that it depends.
Each specific tire/rim combination measures differently, making a hard and fast “maximum tire” number impractical.
The actual measured width of any given tire can be significantly different than the labeled size. While it is generally close enough for a rule of thumb, a tire’s labeled size — “700x25” or “27.5x2.0” is at best an average and is primarily used as a marketing and sales metric for tire comparisons. It is not uncommon for a tire to be listed and sold as “700x38” and have an actual ERTO “40-622” marked on the tire, indicating 40mm actual width.
Another important consideration is the rim profile the tire is mounted on. Depending on variations in the internal rim width, the same tire can have noticeably different widths mounted on different wheels. It is not uncommon for a “700x28” tire to measure 28mm wide on some wheels and 33mm wide on others. In the example below, the same tire is 4mm wider on a “gravel/cyclocross” wheel with a 26mm internal width rim than on a “road/gravel” rim with 21mm internal width.
Please see the specific frame/fork model page for maximum tire size guidelines, keeping in mind that those numbers are not universal.